This is always a question that elicits many different perspectives, which is fine...thankfully we have choices.
With one exception...all the grizzlies that I have taken and those taken by others with me have all been with TSX's...all have been shots in the vitals and clean kills...375H&H's, 338WM and 338-'06. All the bullets entered, expanded, and exited the far side. All shots were well within a hundred yards...a couple were within twenty-five.
TSX's are pretty much all that I handload for use on big game up here, and they shoot very well in my rifles.