I've shot a lot of mule deer and whitetails with these calibers and they all performed as expected. Shoot the one you shoot the best.
6mm Remington 100 gr. Partition & 90 gr. E-tip
25-06 Remington 120 gr. Partition
280 Remington. 140 gr. Partition
280 AI. 140 gr. Partition & 140 gr. Accubond
30-06 165 gr. Partition & 165 gr. Accubond
I shot my muledeer with a 30-06. I would not go any larger. If I go again I will still bring my 06 however my sons 243 maybe going along too. In all reality, they are deer and should not need anything designed for large game.