The weight difference is a factor. Ideally I wanted to be around 475-485 total grains and that will be impossible with 250s. But not the end of the world. I am going to be running Iron Will inserts and collars.I'd lean towards the 250's. I can't remember, might be a fair amount of weight difference from 300-250's in the rampage.
I ran 250's from my vxr at 28.5" but @75#. Had 125 heads and 60 grain insert with a 28" arrow. I'm sure you could make 300's work, but the only disadvantage I see to the 250's is the weight, and depending on what your doing with it that might not be a disadvantage. Keep in mind that some of the insert systems end up taking up a fair amount of shaft, that can help you run a lighter spine.
The weight difference is a factor. Ideally I wanted to be around 475-485 total grains and that will be impossible with 250s. But not the end of the world. I am going to be running Iron Will inserts and collars.