I have a Kifaru tactical frame with a Nomad 2 bag. I bought it probably around 2017 so it may not be the same model you are asking about. I used it for my moose hunt in 2018. It was perfect for hauling moose quarters on the bone. The frame handled the loads as well as I could ask, as well as all my training loads before the hunt. I have kept the pack just in case I end up affording another moose hunt someday. I think it was as perfect as you get for that hunt. Not as bulky to wear as a Barneys or similar pack, but great with a load.
I also got an Exo K2 3500 somewhere around that same time. It became the pack that got the most use when hunting. The Kifaru frame is rigid laterally, it's comfortable but you won't forget you are wearing a frame pack. The Exo moves with my body much better as I move through brush and other terrain. It's rigid vertically but flexes laterally. It handles weight very well, but you can forget you are wearing a frame pack day hunting with a light load. I just got in a K4 but I've only got a few training hikes in it so far. I think it will handle weight even better than the K2, and I never had any complaints about the K2.
For my opinion, the Exo has the better bag layout and frame to hunt with. If I kill I'll take the first load out with the Exo, and I have no problem taking all following loads out with it too. If I'm packing an elk for example though, I like that I can throw some water bottles and my survival kit in the batwings of the Kifaru and haul meat with it after getting the first load to the truck in the Exo. I don't have to unload the gear out of the Exo, just grab the Kifaru and go.
Both are comfortable and work very well with weight. If I'm hauling something really heavy or bulky and awkward that's pretty much what I ordered my Kifaru to do. It excels at that. People on the same moose hunt I went on talked about packing their big raft and motor on frame packs across land to access more territory, I wanted the ability to do the same. I think the Exo handles weight as well as the Kifaru, but the bag I have on the Kifaru handles bulk better.