I just got the FL Kanab 2.0's and the FL Guides and was surprised at how different the fit was between the two. While I haven't had any real field use with either up to this point I'm pretty impressed with the build quality of both. The Guides fit me perfectly in Large; just like they were made for me. I'm something like a 35" waist and 33" inseam. The Kanab 2.0's seemed a little tighter around the thighs and waist as well as slightly shorter in the inseam. The crotch seams to ride up a little higher on the Kanabs as well.
I'm planning on keeping both pants as, in my opinion, they both have a useful place depending on the conditions of the hunt. I thought about sizing up to XL's in the Kanabs but ultimately I think those would be much too big in the waist. While they don't fit me as seamlessly as the Guides, once out in the field I don't think it's going to be enough of a problem for me to even notice. I typically wear 8-11" boots and often gaiters as well so that should help. I don't think the Kanab's will have too much problem with durability but the Guides will certainly be more durable long term, it's just the nature of the materials.
I really like the idea of the suspenders as well, but I'm right at the point of maxing them out. I'm about a 21.5-22" torso length so most guys probably wouldn't have a problem but I'm thinking they may be the reason the crotch feels tighter in the Kanabs. I'll have to play around with that.