I experimented with some smaller revolvers, most happily with a Bowen tuned four inch stainless Blackhawk .44 magnum. It was more comfortable to shoot with full power loads, as the gun rolled in your hand. After taking the Gunsite Backcountry course twice, I became convinced that a single action revolver may be great at many things, but as a fighting handgun (animals), the DA revolver offered too many advantages to not carry. When the Scandium 329 revolvers came out, I instantly got one for my wife and I. So did a bunch of other pilots. They were great to carry, but not great to shoot. I ultimately had a half dozen, between my wife and I, all tuned by Bowen. It got so bad, that during periodic function testing, I would shoot three rounds in my right hand, transfer the revolver to my left hand, and finish the last three shots. My wife basically said the only way she was shooting a whole cylinder was at a bear. She is a strong shooter, but would rather shoot a four inch S&W .500.
As I transitioned back into shooting semi auto pistols as primary, my wife increasingly shot a Glock. She asked why we shot thousands of rounds of 9 and .40, 18 rounds a year of .44 magnum, and were carrying a revolver. She started first carrying a Glock 20 and 29, and I followed suit. We assumed that just as a Glock 17 shot most all 9mm ammo, that the Glock 20 would shoot most all 10mm ammo reliably. We picked 10mm loads based on our assessment of the ability of the bullet to perform on a moose or bear. Those loads were often hard to get in quantity and very expensive. Through trial and error, we realized that many high performance 10mm loads would not function reliably in the Glock 20 and 29. My wife's solution was to use 200 XTP factory ammo, which did run. I tried a variety of other pistols, including the Glock 22 with a KKM barrel, and the S&W 1066/1076.