Yeah even with a good shot I have seen animals and especially coyotes run a long ways. I always put a second shot into the animal if it doesn't drop on the first. No need for them to suffer any longer then they have to even coyotes deserve respect. Not implying anything here so no one get offended just making a general statement. Also I feel as though my success has gone way up on running shots with my AR. You can see where you are hitting in the scope make the adjustment without taking the animal out of your crosshairs and make the hit much easier. With my 22-250 I think I made 2 running shots out of who knows how many. With my AR I am guessing I am close to 80% or higher.