Think I punched it through the shoulders with a Rem 405 sp and a brisk load of 4895. To anchor, either hit cns or break the running gear. I’d opt to try to break both front legs/shoulders.To answer the OP's question, yes, I watched my brother drop his billy with a 45-70 (Marlin Guide Gun), Rem Core-loct 300sp (if I remember correctly). Shot was about 120 yards, hit behind the shoulder and dropped at the shot, DRT. We recovered the bullet on the far shoulder just under the skin.